张在军

博士/副研究员/硕导/副所长

通讯地址:                暨南大学药学院,广州市黄埔大道西601号,邮编:510632
E-mail:                     zaijunzhang@163.com

教育经历:                                                                              
1996 - 2001               学士(临床医学),华中科技大学同济医学院
2002 - 2005               硕士(免疫学),暨南大学生命科学技术学院
2008 - 2012               博士(生物医药),澳门大学中华医药研究院
2012 - 2013               博士后,澳门大学中华医药研究院
2013 - 2015               博士后(香江学者),香港理工大学应用生物与化学系
 
工作经历:     
2014 - 至今               暨南大学药学院新药研究所,副研究员, 硕士研究生导师,副所长
2005 - 2008               暨南大学药学院,助理研究员
  
研究方向:         
治疗神经退行性疾病神经保护活性化合物的研究开发与作用机理研究
 
研究成果:               
曾作为团队核心成员完成1类化学新药“硝酮嗪治疗脑中风”的临床前药效学评价,获得临床研究批件 2 项,正在开展II期临床研究。近年来主持国家十三五新药创制重大专项、国家自然科学基金、广东省自然科学基金、广州市科技计划项目等十余项。共发表论文 100 余篇,其中SCI收录论文 90 余篇,以第一或通讯作者在Free Radical Bio Med, Brit J Pharmacol, Neuropharmacology, J Neurochem等国际知名期刊发表论文 40 篇,论文累计他引超过1000次,多篇论文单篇他引超过100次,Google scholar显示,H指数21。申请发明专利20余项,获授权专利 10 项。国际SCI期刊American Journal of Alzheimer’s Disease and Other Dementias杂志编委,Neural Regeneration ResearchChinese Medicine杂志青年编委。
 
 
发表的部分论文 (English)
 

1. Wu L, Cao J, Li N, Chen H, Liu W, Zhang G, Liu Y, Wang Y, Sun Y, Zhang Z*. Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke. Neuroreport. 2019 Apr 8. doi: 10.1097/WNR.0000000000001256. [Epub ahead of print]
2. Li N, Song X, Wu L, Zhang T, Zhao C, Yang X, Shan L, Yu P, Sun Y, Wang Y, Zhang G*, Zhang Z*. Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats. Neurosci Lett. 2018 Sep 22. pii: S0304-3940(18)30633-5. doi: 10.1016/j.neulet.2018.09.035.
3. Haiyun Chen, Jie Cao, Zeyu Zhu, Gaoxiao Zhang, Luchen Shan, Pei Yu, Yuqiang Wang, Yewei Sun* and Zaijun Zhang*. A novel tetramethylpyrazine derivative protects against glutamate-induced cytotoxicity through PGC1a/Nrf2 and PI3K/Akt signaling pathways. Frontiers in Neuroscience. 2018 Aug 15;12:567. doi: 10.3389/fnins.2018.00567. eCollection 2018.
4. Hu S, Hu H, Mak S, Cui G, Lee M, Shan L, Wang Y, Lin H*, Zhang Z*, Han Y*. A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-5. Methyl-D-aspartate Receptor. Front Pharmacol. 2018 Feb 12;9:73. doi: 10.3389/fphar.2018.00073. eCollection 2018.
5. Gaoxiao Zhang, Tao Zhang, Jianbo Gu, Xinhua Zhou, Liangmiao Wu, Cuimei Li, Wei Liu, Jinzhao Wang, Cheng Long, Yewei Sun, Pei Yu, Yuqiang Wang, Zaijun Zhang*. Neuroprotective Effect of Tetramethylpyrazine Nitrone for ischemic stroke therapy. Neuromolecular Medincine 2018 Mar;20(1):97-111.
6. Gaoxiao Zhang†, Tao Zhang†, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Pei Yu, Yaohui Tang, Guo-yuan Yang, Yuqiang Wang, Yewei Sun*, Zaijun Zhang*. Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats. British Journal of Pharmacology 2018 Feb;175(3):517-531.
7. Xu B, Deng H, Zhang X, Luo J, Zhang G, Zaijun Zhang*, Wang Y, Shan L*. A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. Eur J Pharmacol. 2018 Jan 5;818:158-166.
8. Baojian Guo†, Shengquan Hu†, Chengyou Zheng, Haitao Li, Hongyu Wang, Wei Cui, Shinghung Mak, Tony Chung-Lit Choi, Edmond Dik-Lung Ma, Yuqiang Wang, Simon Ming-Yuen Lee, Zaijun Zhang*, Yifan Han*. Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. Neuropharmacology. 2017 Nov;126:12-24.
9. Xiaopeng Luo†, Yankun Yu†, Zongqin Xiang, Huisu Wu, Seeram Ramakrishna,Yuqiang Wang, Kwok-Fai So, Zaijun Zhang*, Ying Xu*. Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-D-aspartate-induced excitotoxicity. Journal of Neurochemistry 2017 Feb 3. doi: 10.1111/jnc.13970. [Epub ahead of print]
10. Tao Zhang†, Jianbo Gu†, Liangmiao Wu, Ning Li, Yewei Sun, Pei Yu, Yuqiang Wang, Gaoxiao Zhang*, Zaijun Zhang*. Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic hypoperfused rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology. 2017, May 15;118:137-147.
11. Zheng Liu, Wei Cai, Ming Lang, Ruizuo Yan, Zhenshen Li, Gaoxiao Zhang, Pei Yu, Yuqiang Wang, Yewei Sun,* Zaijun Zhang*. Neuroprotective effects and mechanisms of action of multifunctional agents targeting free radicals, monoamine oxidase B and cholinesterase in Parkinson’s disease model. Journal of Molecular Neuroscience. 2017, Jan 31. doi: 10.1007/s12031-017-0891-3.
12. Zheng Liu, Si Yang, Xiaoyong Jin, Gaoxiao Zhang, Baojian Guo, Haiyun Chen, Pei Yu, Yewei Sun,* Zaijun Zhang,* and Yuqiang Wang. Synthesis and Biological Evaluation of Memantine Nitrates as Potential Treatment for Neurodegenerative Diseases. MedChemComm 2016, DOI: 10.1039/c6md00509h.  
13. Chen H, Tan G, Cao J, Zhang G, Yi P, Yu P, Sun Y*, Zhang Z*, Wang Y. Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine Derivatives as Potential Neuroprotective Agents. Chem Pharm Bull (Tokyo). 2016 Oct 14. [Epub ahead of print]
14. Zaijun Zhang†, Gaoxiao Zhang†, Yewei Sun†, Samuel S. W. Szeto, Henry C. H. Law, Quan Quan, Guohui Li, Pei Yu, Eiketsu Sho, Michael K.W. Siu, Simon Ming-Yuen Lee, Ivan Chu, Yuqiang Wang. Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Sci Rep. 2016 Nov 14;6:37148. doi: 10.1038/srep37148.
15. Gaoxiao Zhang, Fen Zhang, Tao Zhang, Jianbo Gu, Cuimei Li, Yewei Sun, Pei Yu, Zaijun Zhang*, Yuqiang Wang. Tetramethylpyrazine nitrone improves neurobehavioral functions and confers neuroprotection on rats with traumatic brain injury. Neurochemical Research 2016 Nov;41(11):2948-2957. [Epub ahead of print]
16. Li, Guohui†; Zhang, Zaijun†; Quan, Quan; Jiang, Ren-Wang; Szeto, Samuel S.W.; Yuan, Shuai; Wong, Wing-Tak; Lam, Herman; Lee, Simon; Chu, Ivan. Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson’s Disease Through LC/MS–Based Multivariate Data Analysis–Guided Fractionation. Journal of Proteome Research 2016, 5;15(8):2595-606. co-first author
17. Guo, Baojian; Zheng, Chengyou; Cheng, Jiehong; Wang, Hongyu; Cai, Wei; Sun, Yewei; Cui, Wei; Wang, Yuqiang; Han, Yi-Fan; Lee, Simon*; Zhang, Zaijun*. Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B. Journal of Agricultural and Food Chemistry 2016, 6;64(26):5324-33.. * corresponding author
18. Zheng CY, Guo BJ, Cai W, Cui W, Mak SH, Wang YQ, Lee SMY, Han YF*, Zhang ZJ*  No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson’s disease mice. Neural Regen Res 2016, 11(8):1339-1346. * corresponding author
19. Kun Zhang, Jiayu Gao, Zaijun Zhang*. Evaluation of Parkinson’s disease in 3 rat models induced by three different unilateral injections of 6-hydroxydopamine. J Pharm Biomed Sci. 2015 Vol. 05 No. 11, 1-6. * corresponding author
20. Longjun Zhu, Yewei Sun, Gaoxiao Zhang, Pei Yu, Yuqiang Wang, Zaijun Zhang*. Radical-scavenging and anti-oxidative activities of TBN in cell-free system and murine H9c2 cardiomyoblast cells. Journal of Antioxidant Activity 2015 Vol-1 Issue 1 Pg. no.- 52. * corresponding author
21. Xinhua Zhou, Longjun Zhu, Liang Wang, Baojian Guo, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang *, Simon Ming-Yuen Lee, Pei Yu, Yuqiang Wang. Protective effect of edaravone in primary cerebellar granule neurons against iodoacetic acid-induced cell injury. Oxid Med Cell Longev. 2015;2015:606981. doi: 10.1155/2015/606981. Epub 2015 Oct 18.* corresponding author
22. Zhao Y, Law HC, Zhang Z*, Lam HC, Quan Q, Li G, Chu IK*. Online coupling of hydrophilic interaction/strong cation exchange/reversed-phase liquid chromatography with porous graphitic carbon liquid chromatography for simultaneous proteomics and N-glycomics analysis. J Chromatogr A. 2015 Aug 19. * corresponding author
23. Zaijun Zhang†, Guohui Li†, Samuel S.W. Szeto, Cheongmeng Chong, Quan Quan, Chen Huang, Wei Cui, Baojian Guo, Yuqiang Wang, Yifan Han, Michael K. W. Siu, Simon Ming-Yuen Lee, Ivan Keung Chu. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson’s disease. Free radical biology and medicine. 2015. Jul;84:331-43.
24. HY Chen, DP Xu, GL Tan, W Cai, GX Zhang, W Cui, JZ Wang, C Long, YW Sun, P  Yu, KW Tsim, ZJ Zhang*, YF Han*, YQ Wang. A Potent Multifunctional Neuroprotective Derivative of Tetramethylpyrazine. Journal of Molecular Neuroscience. 2015. Aug;56(4):977-87. (IF2.7) * corresponding author
25. Fei Sa, Lun Qing Zhang, Cheong Meng Chong, Bao Jian Guo, Sai Li, Zai Jun Zhang *, Hok Man Chan,Ying Zheng, Pui Man Hoi, Simon Ming Yuen Lee*. Discovery of Novel Anti-Parkinsonian Effect of Schisantherin A in in vitro and in vivo. Neuroscience Letters 2015. Mar 11;593:7-12.(* corresponding author
26. Fei SA, Bao Jian Guo, Sai Li, Zai Jun Zhang*, Pui Man Hoi, Ying zheng, Simon Ming Yuen Lee*. Pharmacokinetic Study and Optimal Formulation of New Anti-Parkinson Natural Compound Schisantherin A. Parkinson’s Disease 2015. Article ID 951361 (* corresponding author
27. Huisu Wu, Wei Li, Yewei Sun, Lipeng Xu, Pei Yu, Yuqiang Wang, Zaijun Zhang*. Determination of AL-1 in rat plasma and tissues by high-performance liquid chromatography and its application in AL-1 pharmacokinetic study. J Pharm Biomed Sci 04(05):563-565. 2014* corresponding author
28. Daping Xu; Kun Zhang; Zaijun Zhang*; Yewei Sun; Yuqiang Wang; Pui-Man Hoi; Yifan Han; Simon Lee. A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-kappa B and the PKCalpha/PI3-K/Akt pathways. Neurochemistry International. 78: 76-85. 2014* corresponding author
29. Zaijun Zhang; Daoxu Lai; Liang Wang; Longjun Zhu; Baojian Guo; Yewei Sun; Lipeng Xu; Pei Yu; Libing Zhou; Simon Lee; Yuqiang Wang. Neuroprotective effects of the Andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson’s disease model in vitro and in mice. Pharmacology Biochemistry and Behavior. Apr 12;122C:191-202. 2014.
30. Xu D, Duan H, Zhang Z*, Cui W, Wang L, Sun Y, Lang M, Hoi PM, Han Y, Wang Y, Lee SM*. The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. J Neuroimmune Pharmacol. Mar;9(2):245-58. 2014.* corresponding author
31. Guo B, Xu D, Duan H, Du J, Zhang Z*, Lee SM, Wang Y*. Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo. Biol Pharm Bull. Feb 1;37(2):274-85. 2014 * corresponding author
32. Cui W*, Zhang ZJ*, Hu SQ, Mak SH, Xu DP, Choi CL, Wang YQ, Tsim WK, Lee MY, Rong JH, Han YF. Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction. CNS Neurosci Ther. Mar;20(3):244-52. 2014.  
33. Cui W*, Zhang ZJ*,, Li W, Hu S, Mak S, Zhang H, Han R, Yuan S, Li S, Sa F, Xu D, Lin Z, Zuo Z, Rong J, Ma ED, Choi TC, Lee SM, Han Y. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. British Journal of Pharmacology, 2013 Mar;168(5):1201-14. (*equal contribution)
34. Zhang ZJ, Cui W, Li GH, et al. Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways. Journal of Agricultural and Food Chemistry, 2012 Aug 22;60(33):8171-82.
35. Cui W*, Zhang ZJ*, Li WM, et al. Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase. PLoS One, 2012;7(9):e46253. (*equal contribution)
36. Zhang ZJ, Cheang LC, Wang MW, Li GH, Chu IK, Lin ZX, Lee SM.. Ethanolic extract of Fructus Alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Cell Mol Neurobiol. 2012 Jan;32(1):27-40.
37. Zhang ZJ, Cheang LC, Wang MW, et al. Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish. Int J Mol Med. 2011; 27(2):195-203.
38. Lei BUW *, Yu N *, Zhang ZJ *, Lau E, Siu SO, Lam MPY, Li GH, Chu IK, and Lee SMY. Proteomic Profiling of 6-Hydroxydopamine-treated Zebrafish Using iTRAQ-2D LC-MS/MS Analysis. Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2011;1(2): 199-221. (*equal contribution)
39. Zhang Z, Li S, Jiang J, et al. Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models. Chin Med. 2010 Oct 26;5:36.
40. Zhang Z, Jiang J, Yu P, et al. Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. J Transl Med. 2009 Jul 16;7:62.

扫描二维码分享到微信