江晓间

博士/副研究员/硕士生导师

通讯地址:              暨南大学药学院,广州市黄埔大道西601号,邮编:510632
E-mail:                    xjiang2014@163.com

教育经历:                                                                              
2000 - 2004            学士,广州中医药大学
2004 - 2007            硕士(药物化学),暨南大学
2010 - 2013            博士,新加坡国立大学化学系
2013 - 2015            博士后,以色列理工学院
 
工作经历:     
2015 - 至今            暨南大学药学院新药研究所,副研究员,硕士研究生导师
 

研究方向:         
1.不对称催化合成天然产物及药物活性分子
2.设计并合成新型手性有机配体进行不对称催化交叉偶合反应
3.不对称催化合成含氟手性分子
 
研究成果:             
独立开发出一类新型手性氨基二醚化合物及其制备方法,并成功应用于不对称氟代-环化反应合成系列天然产物的含氟衍生物,拓展药物研发。
 
 
发表的部分论文 (English)
 

1. X. Jiang,* H. Wang, H. He, W. Wang, Y. Wang, Z. Ke, Y.-Y. Yeung,* Enantioseletive fluorination of 3-functionalized oxindoles using electron-rich amino urea catalyst. Adv. Synth. Catal. 2018, 360 (24), 4710–4714. (SCI, IF = 6.5)

2. X. Jiang,* S. Liu, S. Yang, M. Jing, L. Xu, P. Yu, Y. Wang, Y.-Y. Yeung,* Enantioselective bromolactonization of deactivated olefinic acids. Org. Lett. 2018, 20 (11), 3259–3262. (SCI, IF = 6.7)

3. X. Jiang,* F. Zhang, J. Yang, P. Yu, P. Yi, Y. Sun,* Y. Wang, Fluorination-oxidation of 2-hydroxymethylindole using selectfluor. Adv. Synth. Catal. 2017, 359 (5), 853-858. (SCI, IF = 6.5)

4. X. Jiang,* F. Zhang, J. Yang, P. Yu, P. Yi, Y. Sun,* Y. Wang, Synthesis of 3,3-Dihalo-2-oxindoles from 2-Substituted Indoles via Halogenation-Decarboxylation/desulfonamidation-Oxidation Process. Adv. Synth. Catal. 2016, 358 (24), 3938-3942. (SCI, IF = 6.5)     

5. X. Jiang,* J. Yang, F. Zhang, P. Yu, P. Yi, Y. Sun,* Y. Wang, Facile synthesis of 3-halobenzo-heterocyclic-2-carbonyl compounds via in situ halogenation-oxidation. Adv. Synth. Catal. 2016, 358 (16), 2678-2683. (SCI, IF = 6.5)

6. X. Jiang,* J. Yang, F. Zhang, P. Yu, P. Yi, Y. Sun,* Y. Wang, Synthesis of quaternary 3,3-disubstituted-2-oxindoles from 2-substituted indole using selectfluor. Org. Lett. 2016, 18 (13), 3154-3157. (SCI, IF = 6.7)

7. X. Jiang, K. Kulbitski, G. Nisnevich, M. Gandelman,* Enantioselective assembly of tertiary stereocenters via multicomponent chemoselective cross-coupling of geminal chloro(iodo)alkanes. Chem. Sci. 2016, 7, 2762-2767. (SCI, IF = 9.1)

8. X. Jiang, M. Gandelman.* Enantioselective suzuki cross-couplings of unactivated 1-fluoro-1-haloalkanes: synthesis of chiral β, γ, δ and ε-fluoroalkanes. J. Am. Chem. Soc. 2015, 137, 2542-2547. (SCI, IF = 14.4)

9. X. Jiang, S. Sakthivel, K. Kulbitski, G. Nisnevich, M. Gandelman.* Efficient synthesis of secondary alkyl fluorides via suzuki cross-coupling reaction of 1-halo-1-fluoroalkanes. J. Am. Chem. Soc. 2014, 136, 9548-9551.(Highlighted in SYNFACTS, 2014/09) (SCI, IF = 14.4)

10. X. Jiang, C. K. Tan, L. Zhou, Y.-Y. Yeung.* Enantioselective bromolactonization using an S-alkyl thiocarbamate catalyst. Angew. Chem. Int. ed. 2012, 51, 7771-7775. (Highlighted in SYNFACTS, 2012/09) (SCI, IF = 12.1)

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