钟海静-暨南大学-新药研究所

钟海静

博士/副教授/硕士生导师

通讯地址:暨南大学药学院，广州市黄埔大道西601号，邮编：510632
E-mail: hjzhong@jnu.edu.cn

教育经历:
2007 - 2011 学士(药学)，暨南大学国际学院
2011 - 2012 硕士(中药学)，澳门大学中华医药研究院
2012 - 2016 博士(生物医药)，澳门大学中华医药研究院
2016 - 2018 博士后，澳门大学中华医药研究院
2017 - 2019 访问学者/客座研究员(生物医药)，耶鲁大学药理学
师从郑永齐讲席教授

工作经历:
2019 - 至今暨南大学药学院新药研究所，副教授，硕士研究生导师

研究方向:
新药研发和药理机制研究：发现与炎症、肿瘤相关靶点蛋白的26个抑制剂，1个调节剂：基于天然产物和金属化合物的抗肿瘤抗炎分子靶点抑制剂，特别针对于研究蛋白－蛋白相互作用及基因转录，如BRD4、JAK2、STAT3、menin-MLL相互作用等的调节剂。

研究成果：
目前已发表SCI论文53篇，最高影响因子为40.182，其中第一作者（共同一作）16篇，通讯作者1篇，累计影响因子逾300，H-index=25 （Scopus），单篇最高他引次数逾150次，外文专著章节2篇，美国授权专利1项，美国临时专利1项。

荣誉与奖励：
1. 2017 “中国分析测试协会科学技术奖三等奖”，《基于G-四链体的无标记磷光检测平台在环境及生物分析中的应用》，马迪龙、梁重恒、何鸿章、梁嘉豪、鲁莉华、钟海静、王茉荻、林晟、王万河
2. 澳门特别行政区研究生科技研发奖，（2016, Macao Science and Technology Award for Postgraduates）
3. The Postdoc-NeT Fellows 2016, 德国学术交流总署（German Academic Exchange Service, DAAD, Germany）
4. 2014/07/01中药全球化联盟，Travel grant，《Identification of natural product-like protein inhibitors by structure-based virtual screening》

发表的部分论文 (English)

1. H. J. Zhong L. Lu, K. H. Leung, C. C. L. Wong, C. Peng, S. C. Yan, D. L. Ma, Z. Cai, H. M. David Wang, C. H. Leung, An iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent. Chem. Sci. 6, 5400-5408 (2015). 封面内页文章 IF: 9.063
2. H. J. Zhong*, W. Wang, T. S. Kang, H. Yan, Y. Yang, L. Xu, Y. Wang, D. L. Ma, C. H. Leung, A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease. J. Med. Chem. 60, 497-503 (2017). IF: 6.263
3. H. J. Zhong, B. R. Lee, J. W. Boyle, W. Wang, D. L. Ma, P. W. Hong Chan, C. H. Leung, Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction. Chem. Commun. 52, 5788-5791 (2016). IF: 6.29
4. G. J. Yang, H. J. Zhong (共同一作), C. N. Ko, S. Y. Wong, K. Vellaisamy, M. Ye, D. L. Ma, C. H. Leung, Identification of a rhodium(III) complex as a Wee1 inhibitor against: TP53 -mutated triple-negative breast cancer cells. Chem. Commun. 54, 2463-2466 (2018)10.1039/c7cc09384e. IF: 6.290
5.K. J. Wu, H. J. Zhong (共同一作), G. Yang, C. Wu, J. M. Huang, G. Li, D. L. Ma, C. H. Leung, Small Molecule Pin1 Inhibitor Blocking NF-κB Signaling in Prostate Cancer Cells. Chem. Asia J. 13, 275-279 (2018) IF: 3.692
6. K. J. Wu, H. J. Zhong (共同一作), G. Li, C. Liu, H. M. D. Wang, D. L. Ma, C. H. Leung, Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing. Eur. J. Med. Chem. 143, 1021-1027 (2018). IF: 4.816
7. C. H. Leung (导师), H. J. Zhong, H. Z. He, L. Lu, D. S. H. Chan, D. L. Ma, Luminescent oligonucleotide-based detection of enzymes involved with DNA repair. Chem. Sci. 4, 3781-3795 (2013). IF: 9.063
8. C. H. Leung (导师), H. J. Zhong, D. S. H. Chan, D. L. Ma, Bioactive iridium and rhodium complexes as therapeutic agents. Coord. Chem. Rev. 257, 1764-1776 (2013) IF: 14.499
9. C. H. Leung (导师), H. J. Zhong, H. Yang, Z. Cheng, D. S. H. Chan, V. P. Y. Ma, R. Abagyan, C. Y. Wong, D. L. Ma, A metal-based inhibitor of tumor necrosis factor-α. Angew. Chem. Int. Ed. 51, 9010-9014 (2012) IF: 12.102
10. L. Lu, H. J. Zhong (共同一作), B. He, C. H. Leung, D. L. Ma, Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine. Sci. Rep. 6, (2016)10.1038/srep19368. IF: 4.122
11. H. J. Zhong, S. Lin, I. L. Tam, L. Lu, D. S. H. Chan, D. L. Ma, C. H. Leung, In silico identification of natural product inhibitors of JAK2. Methods 71, 21-25 (2015). IF: 3.998
12. H. J. Zhong K. H. Leung, S. Lin, D. S. H. Chan, Q. B. Han, S. L. F. Chan, D. L. Ma, C. H. Leung, Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme. Methods 71, 71-76 (2015). IF: 3.998
13. L. Lu, H. J. Zhong(共同一作), M. Wang, S. L. Ho, H. W. Li, C. H. Leung, D. L. Ma, Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes. Sci. Rep. 5, (2015) IF: 4.122
14. H. J. Zhong, L. J. Liu, C. M. Chong, L. Lu, M. Wang, D. S. H. Chan, P. W. H. Chan, S. M. Y. Lee, D. L. Ma, C. H. Leung, Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo. PLoS ONE 9, (2014) IF: 2.766
15. H. J. Zhong, L. J. Liu, D. S. H. Chan, H. M. Wang, P. W. H. Chan, D. L. Ma, C. H. Leung, Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme. Biochimie 102, 211-215 (2014) IF: 3.188
16. H. J. Zhong, K. H. Leung, L. J. Liu, L. Lu, D. S. H. Chan, C. H. Leung, D. L. Ma, Antagonism of mTOR activity by a kinetically inert rhodium(III) complex. ChemPlusChem 79, 508-511 (2014). IF: 3.205
17. H. Yang, H. J. Zhong (共同一作), K. H. Leung, D. S. H. Chan, V. P. Y. Ma, W. C. Fu, R. Nanjunda, W. D. Wilson, D. L. Ma, C. H. Leung, Structure-based design of flavone derivatives as c-myc oncogene down-regulators. Eur. J. Pharm. Sci. 48, 130-141 (2013) IF: 3.466
18. H. J. Zhong, H. Yang, D. S. H. Chan, C. H. Leung, H. M. Wang, D. L. Ma, A Metal-Based Inhibitor of NEDD8-Activating Enzyme. PLoS ONE 7, (2012) IF: 2.766
19. H. J. Zhong, V. Pui-Yan Ma, Z. Cheng, D. Shiu-Hin Chan, H. Z. He, K. H. Leung, D. L. Ma, C. H. Leung, Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening. Biochimie 94, 2457-2460 (2012) IF: 3.188
20. C. H. Leung (导师), H. J. Zhong, L. Lu, D. S. Chan, D. L. Ma, Luminescent and colorimetric strategies for the label-free DNA-based detection of enzyme activity. Brief. Funct. Genomics 12, 525-535 (2013) IF: 3.783
21. G. J. Yang, C. N. Ko, H. J. Zhong, C. H. Leung, D. L. Ma, Structure-based discovery of a selective KDM5A inhibitor that exhibits anti-cancer activity via inducing cell cycle arrest and senescence in breast cancer cell lines. Cancers 11, (2019)10.3390/cancers11010092. IF: 5.326
22. Y. Dang, C. An, Y. Li, D. Han, X. Liu, F. Zhang, Y. Xu, H. Zhong, M. K. Karim Khan, F. Zou, X. Sun, Neutrophil-mediated and low density lipoprotein receptor-mediated dual-targeting nanoformulation enhances brain accumulation of scutellarin and exerts neuroprotective effects against ischemic stroke. RSC Advances 9, 1299-1318 (2019)10.1039/C8RA06688D. IF: 2.936
23. G. J. Yang, W. Wang, S. W. F. Mok, C. Wu, B. Y. K. Law, X. M. Miao, K. J. Wu, H. J. Zhong, C. Y. Wong, V. K. W. Wong, D. L. Ma, C. H. Leung, Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy. Angew. Chem. Int. Ed. 57, 13091-13095 (2018). IF: 12.102
24. K. Vellaisamy, G. Li, C. N. Ko, H. J. Zhong, S. Fatima, H. Y. Kwan, C. Y. Wong, W. J. Kwong, W. Tan, C. H. Leung, D. L. Ma, Cell imaging of dopamine receptor using agonist labeling iridium(III) complex. Chem. Sci. 9, 1119-1125 (2018). IF: 9.063
25. Y. Li, C. An, D. Han, Y. Dang, X. Liu, F. Zhang, Y. Xu, H. Zhong, X. Sun, Neutrophil affinity for PGP and HAIYPRH (T7) peptide dual-ligand functionalized nanoformulation enhances the brain delivery of tanshinone IIA and exerts neuroprotective effects against ischemic stroke by inhibiting proinflammatory signaling pathways. NJC 42, 19043-19061 (2018). IF: 3.201
26. C. Yang, W. Wang, G. D. Li, H. J. Zhong, Z. Z. Dong, C. Y. Wong, D. W. J. Kwong, D. L. Ma, C. H. Leung, Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction. Sci. Rep. 7, (2017). IF: 4.122
27. K. J. Wu, J. M. Huang, H. J. Zhong, Z. Z. Dong, K. Vellaisamy, J. J. Lu, X. P. Chen, P. Chiu, D. W. J. Kwong, Q. B. Han, D. L. Ma, C. H. Leung, A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells. PLoS ONE 12, (2017). IF: 2.766
28. J. X. Liang, H. J. Zhong (共同一作), G. Yang, K. Vellaisamy, D. L. Ma, C. H. Leung, Recent development of transition metal complexes with in vivo antitumor activity. J. Inorg. Biochem. 177, 276-286 (2017). IF: 3.063
29. T. S. Kang, W. Wang, H. J. Zhong, J. X. Liang, C. N. Ko, J. J. Lu, X. P. Chen, D. L. Ma, C. H. Leung, A rhodium(III)-based inhibitor of autotaxin with antiproliferative activity. Biochim. Biophys. Acta. Gen. Subj. 1861, 256-263 (2017). IF: 3.679
30. T. S. Kang, W. Wang, H. J. Zhong, Z. Z. Dong, Q. Huang, S. W. F. Mok, C. H. Leung, V. K. W. Wong, D. L. Ma, An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB. Cancer Lett. 396, 76-84 (2017). IF: 6.491
31. C. M. Chong, M. T. Kou, P. Pan, H. Zhou, N. Ai, C. Li, H. J. Zhong, C. H. Leung, T. Hou, S. M. Y. Lee, Discovery of a novel ROCK2 inhibitor with anti-migration effects: Via docking and high-content drug screening. Mol. Biosyst. 12, 2713-2721 (2016). IF: 2.92
32. D. L. Ma, Z. Zhang, M. Wang, L. Lu, H. J. Zhong, C. H. Leung, Recent Developments in G-Quadruplex Probes. Chem. Biol. 22, 812-828 (2015). IF: 5.915
33. L. Lu, L. J. Liu, W. C. Chao, H. J. Zhong, M. Wang, X. P. Chen, J. J. Lu, R. N. Li, D. L. Ma, C. H. Leung, Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity. Sci. Rep. 5, (2015) IF: 4.122
34. L. J. Liu, L. Lu, H. J. Zhong, B. He, D. W. J. Kwong, D. L. Ma, C. H. Leung, An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator. J. Med. Chem. 58, 6697-6703 (2015) IF: 6.263
35. K. H. Leung, L. J. Liu, S. Lin, L. Lu, H. J. Zhong, D. Susanti, W. Rao, M. Wang, W. I. Che, D. S. H. Chan, C. H. Leung, P. W. H. Chan, D. L. Ma, Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening. Methods 71, 38-43 (2015) IF: 3.998
36. K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, C. H. Leung, Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe. Chem. Sci. 6, 2166-2171 (2015) IF: 9.063
37. C. H. Leung, S. Lin, H. J. Zhong, D. L. Ma, Metal complexes as potential modulators of inflammatory and autoimmune responses. Chem. Sci. 6, 871-884 (2015) IF: 9.063
38. D. L. Ma, L. J. Liu, K. H. Leung, Y. T. Chen, H. J. Zhong, D. S. H. Chan, H. M. D. Wang, C. H. Leung, Antagonizing STAT3 dimerization with a rhodium(III) complex. Angew. Chem. Int. Ed. 53, 9178-9182 (2014) IF: 12.102
39. D. L. Ma, S. Lin, K. H. Leung, H. J. Zhong, L. J. Liu, D. S. H. Chan, A. Bourdoncle, J. L. Mergny, H. M. D. Wang, C. H. Leung, An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(iii) complex. Nanoscale 6, 8489-8494 (2014) IF: 7.233
40. D. L. Ma, H. Z. He, H. J. Zhong, S. Lin, D. S. H. Chan, L. Wang, S. M. Y. Lee, C. H. Leung, C. Y. Wong, Visualization of Zn 2+ ions in live zebrafish using a luminescent iridium(III) chemosensor. ACS Appl. Mater. Interfaces 6, 14008-14015 (2014) IF: 8.097
41. D. L. Ma, D. S. H. Chan, G. Wei, H. J. Zhong, H. Yang, L. T. Leung, E. A. Gullen, P. Chiu, Y. C. Cheng, C. H. Leung, Virtual screening and optimization of type II inhibitors of JAK2 from a natural product library. Chem. Commun. 50, 13885-13888 (2014) IF: 6.290
42. L. Lu, H. Z. He, H. J. Zhong, L. J. Liu, D. S. H. Chan, C. H. Leung, D. L. Ma, Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex. Sens. Actuators B Chem. 201, 177-184 (2014) IF: 5.667
43. D. L. Ma, H. J. Zhong, W. C. Fu, D. S. H. Chan, H. Y. Kwan, W. F. Fong, L. H. Chung, C. Y. Wong, C. H. Leung, Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex. PLoS ONE 8, (2013) IF: 2.766
44. D. L. Ma, H. Z. He, K. H. Leung, H. J. Zhong, D. S. H. Chan, C. H. Leung, Label-free luminescent oligonucleotide-based probes. Chem. Soc. Rev. 42, 3427-3440 (2013) IF: 40.182
45. K. H. Leung, H. Z. He, H. J. Zhong (共同一作), L. Lu, D. S. H. Chan, D. L. Ma, C. H. Leung, A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3'-5' proofreading activity. Methods 64, 224-228 (2013) IF: 3.998
46. K. H. Leung, H. Z. He, W. Wang, H. J. Zhong, D. S. H. Chan, C. H. Leung, D. L. Ma, Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex. ACS Appl. Mater. Interfaces 5, 12249-12253 (2013) IF: 8.097
47. K. H. Leung, H. Z. He, V. P. Y. Ma, H. J. Zhong, D. S. H. Chan, J. Zhou, J. L. Mergny, C. H. Leung, D. L. Ma, Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe. Chem. Commun. 49, 5630-5632 (2013) IF: 6.290
48. Y. Sun, G. Zhang, Z. Zhang, P. Yu, H. Zhong, J. Du, Y. Wang, Novel multi-functional nitrones for treatment of ischemic stroke. Bioorg. Med. Chem. 20, 3939-3945 (2012) IF: 2.881
49. Y. Sun, P. Yu, G. Zhang, L. Wang, H. Zhong, Z. Zhai, L. Wang, Y. Wang, Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models. J. Neurosci. Res. 90, 1662-1669 (2012) IF: 2.662
50. D. L. Ma, D. C. Shiu-Hin, V. P. Y. Ma, K. H. Leung, H. J. Zhong, C. H. Leung, Current advancements in Aβ luminescent probes and inhibitors of Aβ aggregation. Curr. Alzheimer Res. 9, 830-843 (2012) IF: 3.289
51. D. L. Ma, V. P. Y. Ma, D. S. H. Chan, K. H. Leung, H. J. Zhong, C. H. Leung, In silico screening of quadruplex-binding ligands. Methods 57, 106-114 (2012) IF: 3.998
52. D. L. Ma, H. Z. He, V. P. Y. Ma, D. S. H. Chan, K. H. Leung, H. J. Zhong, L. Lu, J. L. Mergny, C. H. Leung, Label-free sensing of pH and silver nanoparticles using an OR logic gate. Anal. Chim. Acta 733, 78-83 (2012) IF: 5.123
53. C. H. Leung, H. Yang, V. P. Y. Ma, D. S. H. Chan, H. J. Zhong, Y. W. Li, W. F. Fong, D. L. Ma, Inhibition of Janus kinase 2 by cyclometalated rhodium complexes. MedChemComm 3, 696-698 (2012) IF: 2.342

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