代表性论文

          新药所自成立至今共发表SCI论文超130余篇,总影响因子超360新药所骨干人员近6年发表IF3SCI论文50余篇,其中包括Lancet, PNAS , Small , Nature Communications, British Journal of Pharmacology等著名期刊,发表代表性SCI论文如下: 

1. Cui W.; Zhang ZJ.; Li W.; Hu S.; Mak S.; Zhang H.; Han R.; Yuan S.; Li S.; Sa F.; Xu D.; Lin Z.; Zuo Z.; Rong J.; Ma ED.; Choi TC.; Lee SM.; Han Y. The anti-cancer agent SU4312 unexpectedly protects against MPP+-induced neurotoxicity via selective and direct inhibition of neuronal NOS. British Journal of Pharmacology, 2013 Mar;168(5):1201-14. (IF:6.81).
2. Cui, G.; Hung, M.; Shan, L.; Lei, S.; Choi, I.; Zhang, Z.; Hoi, M. P.; Yu, P.; Wang, Y.; Lee, S. M. A novel danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Intl. J. Cardio. 168, 1349-1359, 2013. (IF:4.034).
3. Zhu, Y.; Yu, G.;  Zhang, Y.; Xu, Z.; Wang, Y.; Yan, G.;, He, Q. A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism. Proteomics, 13,169-178, 2013. (IF:3.532).
4. Talantovaa, M.; Sanz-Blascoa, S.; Zhang. X.; Xia, P.; Waseem Akhtara, M.; Okamotoa, S.; Dziewczapolskib, G.; Nakamuraa, T.; Gang, C.; Pratta, A. E.; Kanga, Y-J.; Tua, S.; Molokanovaa, E.; McKerchera, S. R.; Hiresd, A. A.; Sasone, H.; Stoufferf, D. G.; Buczynskif, M. W.; Solomong, J.; Michaelc, S.; Powersg, E. T.; Kellyg, J. W.; Robertsj, A.; Tonga, G.; Fang-Newmeyera, T.; Parkera, J.; Hollanda, E. A.; Zhang, D.; Nakanishia, N.; Chen, H-S, V.; Woloskere, H.; Wang, Y.; Parsonsf, L. H.;  Ambasudhana,R.;   Masliahc, E.; Heinemannb, S. F.; Piña-Crespoa, J. C.; Lipton, S. A. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. PNAS, 110, E2518-2527, 2013. ( IF:9.504).
5. Xu, D.; Duan, H.; Du, J.; Zhang, Z.; Cui, W.; Wang, L.; Sun, Y.; Lang, M.; Hoi, P. M.; Han, Y.; Wang, Y.; Lee, S. M. The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. J. Neuroimmun. Pharmacol. 9, 245-258, 2014. (IF:3.664).
6. Xu, D.; Zhang, K.; Zhang, Z.; Sun, Y.; Guo, B.; Wang, Y.; Hoi, P. M.; Han, Y.; Lee, S. M. A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways. Neurochem. Int. 2014.(IF:3.603).
7. Cui, W.; Zhang, Z.; Hu, S.; Mak, S.; Xu, D.; Choi, C.; Wang, Y.; Tsim, K.; Lee, M.; Rong, J.; Han, Y. Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction. CNS Neurosci. Ther.  20, 244-252, 2014.(IF:3.495).
8. Lang, M.; Yan, R.; Wang, Y.; Yu, P. A selective O- and N-acylation protocol for carbamyl chloride. Chin. J. Org. Chem. 34(6):1227, 2014.(IF:4.805).
9. Xu, L.; Li, Y.; Wan, S.; Wang, Y.; Yu, P. Apocynin nitrone protects rats from LPS-mediated acute lung injury via inhibition of NADPH oxidase. Intl. Immunopharmacol. 20, 377-382, 2014. (IF:3.118).
10. Zhao, Y.; Szeto, S. S. W.; Kong, R. P. W.; Law, C. H.; Li, G.; Quan, Q.; Zhang, Z.; Wang, Y.; Chu, I. K. Online two-dimensional porous graphitic carbon/reversed phase liquid
11.  chromatography platform applied to shotgun proteomics and glycoproteomics. Anal Chem  2014 Dec 16;86(24):12172-9. (IF: 6.042).
12. Zhao Y, Law HC, Zhang Z, Lam HC, Quan Q, Li G, Chu IK. Online coupling of hydrophilic interaction/strong cation exchange/reversed-phase liquid chromatography with porous graphitic carbon liquid chromatography for simultaneous proteomics and N-glycomics analysis. J Chromatogr A. 2015 Aug 19. (IF: 3.716).
13. Law, C. H.; Szeto, S. S. W.; Kong, R. P. W.; Zhang, Z.; Wang, Y.; Quan, Q.; Lee, S. M. Y. Chu, I. K. A versatile reversed phase-strong cation exchange-reversed phase (RP-SCX-RP) multidimentional liquid chromatography platfprm for qualitative and quantitative shotgun proteomics. Analyst. 140(4):1237-52, 2015. (IF:3.864).
14. Zhang, Z.; Li, G.; Szeto, S. S.; Chong, C.; Quan, Q.; C.; Cui, W.; Guo, B.; Wang, Y.; Han, Y.; Siu, M.; Lee, S. M.; Chu, I. K. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro     and in vivo models of Parkinson's disease. Free Radic Biol. Med. 84:331-43, 2015. (IF:6.02).
15. Li, Y.; Yan, H.; Zhang, Z.; Zhang, G.; Sun, Y.; Yu, P.; Wang, Y.; Xu, L. Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signaling pathway. Br. J. Pharmacol. 172(12):3151-8, 2015. (IF:6.81).
16. Lee, R.; Shan, L.; Zhang, Z.; Wang, Y.; Yang, C.; Kwan, Y-W.; Lee, S. M.; Hoi, M. P.; Chan, S-W.; Cheung, A. C.; Cheung, K-H. Relaxation effect of a novel danshensu/tetramethylpyrazine derivative on rat mesenteric arteries. Eur. J. Pharmacol. 761:153-60, 2015. (IF:3.04).
17. Quan, Q.; Szeto, S. S. W.; Zhang, Z.; Wang, Y.; Chu, I. K. Fully automated multidimensional reversed-phase liquid chromatography with tandem anion/cation exchange columns for simultaneous global endogenous tyrosine nitration detection, integral membrane protein characterization, and quantitative proteomics mapping in cerebral infarcts. Anal. Chem. 87(19):10015-24, 2015. (IF:6.042).
18. Zhou, X.; Zhu, L.; Wang, L.; Guo, B.; Zhang, G.; Sun, Y.; Zhang, Z.; Lee, M-Y.; Yu, P.; Wang, Y. Protective effect of edaravone in primary cerebellar granule neurons against iodoacetic acid-induced cell injury, Oxidat. Med. Cell. Longev. 2015:606981, 2015. (IF:4.936).
19. Li, Guohui.; Zhang, Zaijun.; Quan, Quan; Jiang, Ren-Wang; Szeto, Samuel S.W.; Yuan, Shuai; Wong, Wing-Tak; Lam, Herman; Lee, Simon; Chu, Ivan. 18. Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson’s Disease Through LC/MS–Based Multivariate Data Analysis–Guided Fractionation. Journal of Proteome Research 2016, 5;15(8):2595-606. (IF:3.95).
20. Guo, Baojian; Zheng, Chengyou; Cheng, Jiehong; Wang, Hongyu; Cai, Wei; Sun, Yewei; Cui, Wei; Wang, Yuqiang; Han, Yi-Fan; Lee, Simon*; Zhang, Zaijun*. Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B. Journal of Agricultural and Food Chemistry 2016, 6;64(26):5324-33. (IF:3.412).
21. Liu, W.; Lang, M.; Youdim, M.B.H.; Amit, T.; Sun, Y.; Zhang, Z.; Wang,Y.; Weinreb, O. Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease, Neuropharmacology. 2016.06.013. (IF:4.249).
22. Jiang, X.; Yang, J.; Zhang, F.; Yu, P.; Sun, Y,; Wang, Y. Facile synthesis of 3-halobenzo-heterocyclic-2-carbonyl compounds via in situ halogenation-oxidation. Adv. Synth. Catal. DOI: 10.1002/adsc.201600431, 2016. (IF:5.123).
23. Jiang, X.; Yang, J.; Zhang, F.; Yu, P.; Sun, Y,; Wang, Y. Synthesis of quaternary 3,3-disubstituted 2-oxindoles from 2-substituted indole using selectfluor. Org. Lett. 18, 3154-3157, 2016. (IF:6.492).
24. Zhao, H.; Osborne, O. J.; Lin, S.; Ji, Z.; Wang, Y.; Nel, A. E.; Lin, S. Lanthanide hydroxide nanoparticles induce angiogenesis via ROS-sensitive signaling.  Small, 2016.  (IF:9.598).
25. Liu, W.; Rabinovich, A.; Nash, Y.; Frenkel, D.; Wang, Y.; Youdim, Y.; Weinreb, O. Neuroprotective and anti-inflammatory effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells. Neuropharmacology  doi: 10.1016/j.neuropharm.2016.10.028.2016. (IF:4.249).
26. Wang, L.; Chan, J. Y-W.; Zhou, X.; Cui, G.; Yan, Z.; Wang, L.; Yan, R.; Di, L.;  Wang, Y.; Hoi, M. P-M.; Shan, L.; Lee, S. M-Y. A novel agent enhances the chemotherapeutic efficacy of doxorubicin in MCF-7 breast cancer cells. Front Pharmacol. 2016 Aug 10;7:249. (IF: 3.831).
27. Xu, D.; Chen, H.; Mak, S.; Hu, S.; Tsim, K.W.; Hu, Y.; Sun, Y.; Zhang, G.; Wang, Y.;  Zhang, Z.; Han, Y. Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochem Int.  2016 Oct;99:194-205. (IF: 3.603).
28. Jiang, X.; Zhang, F.; Yang, J.; Yu, P.; Yi, P.; Sun, Y.; Wang, Y. Fluorination-oxidation of 2-hydroxymethylindole. Adv. Synth. Catal. 2016. (IF:5.123).
29. Cui, G.; Shan, L.; Chen, Y.; Zhou, H.; Wang, Y.; Lee, M-Y. A new danshensu derivative protects against 6-hydroxydopamine-induced neurotoxicity in vitro and in vivo. Am J Chin Med. 2016;44(7):1349-1361. Epub 2016 Oct 27. (IF:3.12).
30. Cui, G.; Ho, A. W.; Lee, S-M.; Wang, Y.; Hoi, M. P. Development of the novel antiplatelet agent ADTM, originating from traditional Chinese medicine: a chemical proteomic analysis and in-vivo assessment of efficacy in an animal model. Lancet, 388 Suppl 1:S37. 2016. (IF:53.254).
31. Wang, Q.; Peng, K.; Chen, W.; Cao, Z.; Zhu, P.; Wang, Y.; Zhou, H.; Jiang, Z. Development of double chain phosphatidylcholine functionalized polymeric monoliths for immobilized membrane chromatography. J. Chromat. A. 1479, 97-106, 2017. (IF:3.716).
32. Zhong, H.; Wang, W.; Kang, T-S.; Yan, H.; Yang, Y.; Xu, L.; Wang, Y.; Ma, D-L.; Leung, C-H. A Rhodium(III) complex as an inhibitor of neural precursor cell expressed, developmentally down-regulated 8-activating enzyme with in vivo activity against inflammatory bowel disease. J. Med. Chem. 60, 497-503, 2017.  (IF:6.253).
33. Law, C. H.; Szeto, S. S. W.;  Quan, Q.; Zhao, Y.; Zhang, Z.; Krakovska, O.; Leong, T. L.; Zheng, C.; Lee, S,; Siu, K. W.; Wang, Y.; Chu, I. Characterization of the molecular mechanisms underlying the chronic phase of stroke in a cynomolgus monkey model of induced cerebral ischemia. J. Proteomic. Res. 2017. (IF:3.95).
34. Luo, X.; Yu, Y.; Xiang, Z.; Wu, H.; Ramakrishna, S.; Wang, Y.; So, K-F.; Zhang, Z.; Xu, Y. Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-D-aspartate-induced excitotoxicity.  J. Neurochem. 2017. (IF:4.609).
35. Zhang, T.; Gu, J.; Wu, L.; Li, N.’ Sun, Y.; Yu, P.; Wang, Y.; Zhang, G.;  Zhang. Z. Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology. 2017, 118:137-147. (IF:4.249).
36. Guo, B.; Hu, S.; Zheng, C.; Wang, H.; Luo, F.; Li, H.; Cui, W.; Yang, X.; Cui, G.; Mak, S.; Choi, T. C.; Ma,  E. D.; Wang, Y.; Lee, S. M. Y.; Zhang, Z.; Han, Y. Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. Neuropharmacol. 2017, 126:12-24. (IF:4.249).
37. Tu, S.; Akhtar, M. W.; Escorihuela, R.; Amador-Arjona, A.; Swarup, V.; Parker, J.; Zaremba, J. D.; Holland, T.; Bansal, N.; Holohan, D. R.;  Lopez, K.;  Ryan, S. D.; Chan, S. F.; Yan, L.; Zhang, X.; Huang, X.; Sultan, A.; McKercher, S. R.; Ambasudhan, R.;  Xu, H.; Wang, Y.; Geschwind, D. H.; Roberts, A. J.; Terskikh, A. V.; Masliah, E.; Lipton, S. A.; Nakanishi, N. NitroSynapsin therapy for the mouse MEF2C haploinsufficiency model of human autism. Nat.Commun. 2017, 8(1):1488. (IF:12.353).
38. Bao-Jian Guo, Zhao-Xiang Bian, Hong-Cong Qiu, Yitao Wang, Ying Wang. Biological and clinical implications of herbal medicine and natural products for the treatment of IBD. Annals of the New York Academy of Sciences. 2017 Aug; 1401(1):37-48. (IF:4.277).
39. Hu S, Hu H, Mak S, Cui G, Lee M, Shan L, Wang Y, Lin H*, Zhang Z*, Han Y*. A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor. Front Pharmacol.  2018 Feb 12;9:73. (IF: 3.831).
40. Xu, B.; Deng, H.; Zhang, X.; Luo. J.; Zhang, G.;  Zhang, Z.; Wang. Y.; Shan. L. A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. Eur. J Pharmacol. 2018, 818:158-166. (IF:3.04).
41. Zhang, G.; Zhang, T.; Li, N.; Wu, L.; Gu, J.; Li, C.; Zhao, C.; Liu, W.; Shan, L.; Yu, P.; Yang, X.; Tang, Y.; Yang, G.; Wang, Y.; Sun, Y.; Zhang, Z. Tetramethylpyrazine nitrone activates AKT/CREB pathway through increasing BDNF expression to promote post-ischemic neuroregeneration and recovery of neurological functions in rats. Br. J. Pharmacol. 2018, 175(3):517-531. (IF:6.81).
42. Wang, Q.; Wu, H.; Peng, K.; Jin, H.; Shao, H.; Wang, Y.; Crommen, J.; Jiang, Z. Hydrophilic polymeric monoliths containing choline phosphate for separation science applications. Anal. Chim. Acta. 2018, 999:184-189. (IF:5.123).
43. Jiang, X.; Liu, S.; Yang, S.; Jiang, M.; Xu, L.; Yu, P.; Wang, Y.; Yeung, Y. Enantioselective Bromolactonization of Deactivated Olefinic Acids. Org. Lett. 2018, 20(11): 3259-3262. (IF:6.492).
44. Cui, G.; Xin, Q.; Tseng, H.H.L.; Hoi, M. P.; Wang, Y.; Yang, B.; Choi, I.; Wang. Y.; Yuan, R.; Chen, K.; Cong, W.; Lee, S. M. A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice. Pharmacol. Res. 2018, 134:109-117. (IF:4.897).
45. Jiang, X.; Wang, H.; He, H.; Wang, W.; Wang, Y.; Ke, Z.; Yeung, Y. Enantioseletive fluorination of 3-functionalized oxindoles using electron-rich amino urea catalyst.  Adv. Syn. & Catal. 2018, 360, 4710-4714. (IF:5.123).
46. Wang, Q,; Jin, H.; Xia, D.; Shao, H.; Peng, K.; Liu, X.; Huang, H.;  Zhang, Q.; Guo, J.; Wang, Y.; Crommen, J.; Gan, N.; Jiang, Z. Biomimetic Polymer-Based Method for Selective Capture of C-Reactive Protein in Biological Fluids. ACS Appl Mater Interfaces. 2018 Dec 12;10(49):41999-42008. (IF:8.097).
47. Chen, H.; Cao, J.; Zhu, Z.; Zhang, G.; Shan, L.; Yu, P.; Wang, Y.; Sun, Y.; Zhang, Z. A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways. Front Neurosci. 2018, 12:567. (IF:3.877).
48. Hu, S.; Mak, S.; Zuo, X.; Li, H.; Wang, Y.; Han, Y. Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla. Front Pharmacol. 2018, 9:768. (IF:3.831).
49. Zhou, X.; Xiao, W.; Su, Z.; Cheng, J.; Zheng, C.; Zhang, Z.; Wang, Y.; Wang, L.; Xu, B.; Li, S.; Yang, X.; Pui, Man Hoi M. J. Hippocampal proteomic alteration in triple transgenic mouse model of Alzheimer's disease and implication of PINK 1 regulation in donepezil treatment. Proteome Res. 2018. (IF:3.95).
50. Jiang, J.; Jian, Q.; Jing, M.; Zhang, Z.; Zhang, G.; Shan, L.; Yu, P.; Wang, Y.; Xu, L. The novel N-methyl-d-aspartate receptor antagonist MN-08 ameliorates lipopolysaccharide-induced acute lung injury in mice. Int. Immunopharmacol. 2019, 66:109-118. (IF:3.118).
51. Bao-Jian Guo.;  Zhuyun Liu.; Mo-Yu Dinga.; Feng Li.; Mei Jing.; Li-Peng Xu.; Yu-Qiang Wang.; Zai-Jun Zhang.; Yitao Wang.; Decai Wang.; Guo-Chun Zhou.; Ying Wang. Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice. Biochem Pharmacol 2019 May;163:416-424. (IF: 4.235).

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